Propanoyl-CoA C-acyltransferase

Propanoyl-CoA C-acyltransferase
Identifiers
EC number 2.3.1.176
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a propanoyl-CoA C-acyltransferase (EC 2.3.1.176) is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA \rightleftharpoons CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA and propanoyl-CoA, whereas its two products are CoA and 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase. Other names in common use include peroxisomal thiolase 2, sterol carrier protein-, SCP, and PTE-2 (ambiguous). This enzyme participates in ppar signaling pathway.

Propanoyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

References